Palms is bordered by Culver City to the south, Rancho Park and West Los Angeles to the north, and Mar Vista to the west. The district's boundaries are National Blvd. and the Rosa Parks Freeway (I-10) on the north, the Culver City boundary on the south, and the San Diego Freeway on the west. Principal thoroughfares include National, Palms, Venice, and Sepulveda boulevards and Overland and Motor avenues.

The portion of Palms bounded by Overland, Sepulveda, National, and Charnock Road was developed just before World War II as Westside Village and is considered by its property owners' group (the Westside Village Civic Association) to be a distinct neighborhood.
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Mar Vista is located near the center of LA's West Side. The city of Santa Monica lies to the northwest, West Los Angeles to the north, Palms to the northeast, Culver City to the east, Del Rey to the southeast, and Marina del Rey and Venice to the southwest. Its approximate boundaries are the city limits of Culver City and the San Diego Freeway (I-405) on the northeast, Culver Boulevard on the southeast, Walgrove Avenue (north of Washington Boulevard) and Lincoln Boulevard (south of Washington) on the southwest, and the Santa Monica City limits and the Santa Monica Freeway (I-10) on the northwest. Major thoroughfares through the district include Palms, Venice, Sawtelle, Inglewood, and Grand View Boulevards, McLaughlin, Barrington, Short, and Centinela Avenues, and Beethoven Street. Most of the district uses the 90066 ZIP code. The northern and southern portions of Mar Vista are separated by a narrow strip of Culver City around Washington Boulevard. That portion of Culver City has an Los Angeles address and is part of the Mar Vista school district.

Westdale, the area around National Boulevard, while usually considered a part of Mar Vista, is sometimes thought of as a separate neighborhood.

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